ol201314m_si_001.pdf (270 kB)

Enantioselective Cyclization of 4-Alkenoic Acids via an Oxidative Allylic C–H Esterification

Download (270 kB)
journal contribution
posted on 01.07.2011 by Kazuhiro Takenaka, Mitsutoshi Akita, Yugo Tanigaki, Shinobu Takizawa, Hiroaki Sasai
An enantioselective intramolecular oxidative cyclization of 4-alkenoic acids was developed. The reaction proceeded via a π-allyl Pd intermediate generated by an allylic C–H activation to give γ-lactone derivatives with moderate to good enantioselectivity. Spiro bis(isoxazoline) ligand, SPRIX, was indispensable for this asymmetric transformation.