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Enantioselective 1,1-Arylborylation of Alkenes: Merging Chiral Anion Phase Transfer with Pd Catalysis

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journal contribution
posted on 11.03.2015, 00:00 by Hosea M. Nelson, Brett D. Williams, Javier Miró, F. Dean Toste
A palladium-catalyzed three-component coupling of α-olefins, aryldiazonium salts, and bis­(pinacolato)­diboron affords direct access to chiral benzylic boronic esters. This process is rendered highly enantioselective using an unprecedented example of cooperative chiral anion phase transfer and transition-metal catalysis.