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Enantio- and Diastereoselective Tandem Zn-Promoted Brook Rearrangement/Ene−Allene Carbocyclization Reaction

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journal contribution
posted on 16.04.2009 by Rozalia Unger, Fritz Weisser, Nicka Chinkov, Amnon Stanger, Theodore Cohen, Ilan Marek
The zinc-catalyzed addition of various alkynes to acylsilanes followed by a Zn−Brook rearrangement and either the Zn−ene−allene or Zn−yne−allene cyclization led to the enantio- and diastereoselective formation of carbocycles in a single-pot operation.