Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des-tert-butyl Janadolide and Its Biological Evaluation
journal contributionposted on 27.02.2018 by Paresh R. Athawale, Gorakhnath R. Jachak, Anurag Shukla, Dhanasekaran Shanmugam, D. Srinivasa Reddy
Any type of content formally published in an academic journal, usually following a peer-review process.
To identify novel antitrypanosomal agents based on Janadolide, a potent macrocyclic polyketide–peptide hybrid, a macrolactonization strategy was explored. We prepared des-tert-butyl Janadolide and evaluated its antitrypanosomal activity. Our findings suggest that the tert-butyl group is necessary for the desired bioactivity.