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Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des-tert-butyl Janadolide and Its Biological Evaluation

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journal contribution
posted on 27.02.2018 by Paresh R. Athawale, Gorakhnath R. Jachak, Anurag Shukla, Dhanasekaran Shanmugam, D. Srinivasa Reddy
To identify novel antitrypanosomal agents based on Janadolide, a potent macrocyclic polyketide–peptide hybrid, a macrolactonization strategy was explored. We prepared des-tert-butyl Janadolide and evaluated its antitrypanosomal activity. Our findings suggest that the tert-butyl group is necessary for the desired bioactivity.