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Efficient, Stereoselective Synthesis of trans-2,5-Disubstituted Morpholines

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journal contribution
posted on 18.03.2004, 00:00 by Brian A. Lanman, Andrew G. Myers
Enantio- and diastereoselective syntheses of trans-2,5-disubstituted morpholine derivatives are described. The routes are initiated by the reaction of enantiopure epoxides (2) with amino alcohols (3) and address the problem of regioselective hydroxyl activation−ring closure of the resulting amino diol adducts for (amino alcohol-derived) alkyl substituents of different steric demands.