ol049861t_si_001.pdf (3.26 MB)

Efficient, Stereoselective Synthesis of trans-2,5-Disubstituted Morpholines

Download (3.26 MB)
journal contribution
posted on 18.03.2004, 00:00 by Brian A. Lanman, Andrew G. Myers
Enantio- and diastereoselective syntheses of trans-2,5-disubstituted morpholine derivatives are described. The routes are initiated by the reaction of enantiopure epoxides (2) with amino alcohols (3) and address the problem of regioselective hydroxyl activation−ring closure of the resulting amino diol adducts for (amino alcohol-derived) alkyl substituents of different steric demands.

History

Exports