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Efficient Asymmetric Syntheses of 1‑Phenyl-phosphindane, Derivatives, and 2- or 3‑Oxa Analogues: Mission Accomplished

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journal contribution
posted on 16.05.2014 by Slavko Rast, Barbara Mohar, Michel Stephan
A highly enantioselective synthesis of unsubstituted 1-phenyl-phosphindane and its P-borane and P-oxide derivatives was effectively established via a new fluoride-triggered desilylative carbocyclization strategy. Preparation of the “oxygen atom-doped” 1-phenyl-3-oxa-1-phosphindane-P-borane analogue was otherwise achieved via a tandem P-α-iodination–intra-O-alkylation.

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