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Divergent Synthesis of Functionalized Carbocycles through Organosilane-Directed Asymmetric Alkyne–Alkene Reductive Coupling and Annulation Sequence

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journal contribution
posted on 07.11.2012, 00:00 by Jie Wu, Yi Pu, James S. Panek
An organosilane-directed alkyne–alkene reductive coupling of readily available propargylsilanes is used to access densely functionalized chiral allylsilanes. The divergent reactivity of the allylsilanes can be controlled to afford a range of novel carbocyclic ring systems through an intramolecular allylation, [3+2] annulation, and Sakurai-like homodimerization.