Direct N-Acetyl Enamine Formation: Lithium Bromide Mediated Addition of Methyllithium to Nitriles
journal contributionposted on 31.08.2006 by Cécile G. Savarin, Geneviève N. Boice, Jerry A. Murry, Edward Corley, Lisa DiMichele, Dave Hughes
Any type of content formally published in an academic journal, usually following a peer-review process.
An improved protocol for N-acetyl enamine formation is disclosed which involves LiBr-mediated addition of MeLi to substituted nitriles. The resulting enamides are isolated in high yields and excellent purity which permits subsequent hydrogenation at very low catalyst loading.