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Direct N-Acetyl Enamine Formation:  Lithium Bromide Mediated Addition of Methyllithium to Nitriles

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journal contribution
posted on 31.08.2006 by Cécile G. Savarin, Geneviève N. Boice, Jerry A. Murry, Edward Corley, Lisa DiMichele, Dave Hughes
An improved protocol for N-acetyl enamine formation is disclosed which involves LiBr-mediated addition of MeLi to substituted nitriles. The resulting enamides are isolated in high yields and excellent purity which permits subsequent hydrogenation at very low catalyst loading.