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Direct, Palladium-Catalyzed, Multicomponent Synthesis of β-Lactams from Imines, Acid Chloride, and Carbon Monoxide

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journal contribution
posted on 31.08.2006 by Rajiv Dhawan, Rania D. Dghaym, Daniel J. St. Cyr, Bruce A. Arndtsen
A new palladium-catalyzed synthesis of 3-amido-substituted β-lactams is reported. This process involves the one-pot coupling of four components, imines, carbon monoxide, and acid chloride, providing a flexible route to construct this class of heterocycle. The generation of β-lactams with two different imines can also be accomplished, providing a method to assemble these products with independent control over five separate substituents.

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