Direct, Palladium-Catalyzed, Multicomponent Synthesis of β-Lactams from Imines, Acid Chloride, and Carbon Monoxide
journal contributionposted on 31.08.2006 by Rajiv Dhawan, Rania D. Dghaym, Daniel J. St. Cyr, Bruce A. Arndtsen
Any type of content formally published in an academic journal, usually following a peer-review process.
A new palladium-catalyzed synthesis of 3-amido-substituted β-lactams is reported. This process involves the one-pot coupling of four components, imines, carbon monoxide, and acid chloride, providing a flexible route to construct this class of heterocycle. The generation of β-lactams with two different imines can also be accomplished, providing a method to assemble these products with independent control over five separate substituents.