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Direct Effects of Carbon Nanotubes on Dendritic Cells Induce Immune Suppression Upon Pulmonary Exposure

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journal contribution
posted on 26.07.2011 by Alexey V. Tkach, Galina V. Shurin, Michael R. Shurin, Elena R. Kisin, Ashley R. Murray, Shih-Houng Young, Alexander Star, Bengt Fadeel, Valerian E. Kagan, Anna A. Shvedova
Pharyngeal aspiration of single-walled carbon nanotubes (SWCNTs) caused inflammation, pulmonary damage, and an altered cytokine network in the lung. Local inflammatory response in vivo was accompanied by modified systemic immunity as documented by decreased proliferation of splenic T cells. Preincubation of naïve T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic cell function.