Derisking Development by a Cocrystallization Screen of a Novel Selective Inhaled JAK-STAT inhibitor
journal contributionposted on 15.11.2018 by Antonio Llinas, Rafael Barbas, Mercè Font-Bardia, Amir Smailagic, Rafel Prohens
Any type of content formally published in an academic journal, usually following a peer-review process.
The discovery and detailed characterization of several new solid forms of a novel selective inhaled JAK-STAT inhibitor are described. Using a holistic cocrystallization screen approach to explore its formulation landscape, we decrease the risk of future potential development failures due to a nonoptimal pharmacokinetic lung profile or undesired lung effects in humans.