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Cytotoxic Polyisoprenyl Benzophenonoids from Garcinia subelliptica

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journal contribution
posted on 23.04.2010 by Li-Jie Zhang, Chun-Tang Chiou, Jing-Jy Cheng, Hui-Chi Huang, Li-Ming Yang Kuo, Chia-Chin Liao, Kenneth F. Bastow, Kuo-Hsiung Lee, Yao-Haur Kuo
Six new polyisoprenyl benzophenonoids, (±)-garcinialiptone A (1, 2), garcinialiptone B (3), (−)-cycloxanthochymol (4), garcinialiptone C (5), and garcinialiptone D (6), along with three known compounds, xanthochymol (7), isoxanthochymol (8), and cycloxanthochymol (9), were isolated from the fruits of Garcinia subelliptica. The structures of 16 were elucidated by spectroscopic analysis. Biological evaluation showed that all compounds 19 exhibited cytotoxic activity against a small panel of human tumor cell lines (A549, DU145, KB, vincristine-resistant KB).

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