Cytotoxic Polyisoprenyl Benzophenonoids from Garcinia subelliptica
journal contributionposted on 23.04.2010, 00:00 by Li-Jie Zhang, Chun-Tang Chiou, Jing-Jy Cheng, Hui-Chi Huang, Li-Ming Yang Kuo, Chia-Chin Liao, Kenneth F. Bastow, Kuo-Hsiung Lee, Yao-Haur Kuo
Six new polyisoprenyl benzophenonoids, (±)-garcinialiptone A (1, 2), garcinialiptone B (3), (−)-cycloxanthochymol (4), garcinialiptone C (5), and garcinialiptone D (6), along with three known compounds, xanthochymol (7), isoxanthochymol (8), and cycloxanthochymol (9), were isolated from the fruits of Garcinia subelliptica. The structures of 1−6 were elucidated by spectroscopic analysis. Biological evaluation showed that all compounds 1−9 exhibited cytotoxic activity against a small panel of human tumor cell lines (A549, DU145, KB, vincristine-resistant KB).