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Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae

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posted on 07.06.2018 by Jaeyoung Kwon, Hyaemin Lee, Young Hye Seo, Jieun Yun, Jun Lee, Hak Cheol Kwon, Yuanqiang Guo, Jong Soon Kang, Jae-Jin Kim, Dongho Lee
A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (17). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2–6.0 μM.

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