Cytotoxic Diterpenoids from Sapium insigne
journal contributionposted on 27.04.2012 by Hong-Bing Liu, Hua Zhang, Jin-Hai Yu, Cheng-Hui Xu, Jian Ding, Jian-Min Yue
Any type of content formally published in an academic journal, usually following a peer-review process.
Chemical investigation into the twigs and leaves of Sapium insigne afforded seven new diterpenoids, sapinsignoids A–G (1–7), together with 10 known diterpenoids. The structures of 1–7 were assigned on the basis of detailed spectroscopic analysis and chemical degradation. Compounds 1–4 exhibited significant cytotoxicity against the A-549 tumor cell line (IC50 0.2–1.8 μM), while compounds 1–3 showed moderate cytotoxicity against the HL-60 cell line (IC50 2.7–6.5 μM).