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Cycloisomerization of Allene–Enol Ethers under Bi(OTf)3 Catalysis

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journal contribution
posted on 20.02.2015 by Pierrick Ondet, Amélie Joffrin, Ilhem Diaf, Gilles Lemière, Elisabet Duñach
The cycloisomerization of allene–enol ethers under Bi­(OTf)3 catalysis was developed as a novel “atom-economic” tool for accessing interesting functionalized cyclopentene rings. Bi­(OTf)3 was shown to promote selectively the activation of the enol ether moiety of the substrate. This catalytic methodology was further extended to the synthesis of dihydrofuran and oxaspirocycle derivatives.