CuBr-Catalyzed α‑Arylation and Aerobic Oxidative Dehydrogenative C–N Coupling for the Synthesis of Spiro[cyclohexane-1,12′-isoindolo[1,2‑b]quinazolin]-10′-one Derivatives
journal contributionposted on 30.03.2020 by Fang Dong, Jian-Quan Liu, Xiang-Shan Wang
Any type of content formally published in an academic journal, usually following a peer-review process.
A copper-catalyzed approach was disclosed for C(sp3)–C(sp2) bond formation via an α-arylation of carbonyl, and the subsequent oxidative dehydrogenation coupling occurred to form a C(sp3)–N bond, wherein O2 served as a green oxidant. This protocol provided a domino method for the synthesis of spiro[cyclohexane-1,12′-isoindolo[1,2-b]quinazolin]-10′-ones containing a nitrogen-substituted quaternary carbon center.