Copper Catalyzed C−H Functionalization for Direct Mannich Reactions

2011-03-04T00:00:00Z (GMT) by Magnus Rueping Nikita Tolstoluzhsky
A protocol for a practical and direct addition of α- and γ-alkyl azaarenes to N-sulfonyl aldimines has been developed. Copper salts act as efficient Lewis acid catalysts for direct Mannich-type reactions providing a mild and fast access to various functionalized heterocycles.