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Copper-Catalyzed Amination of Primary Benzylic C−H Bonds with Primary and Secondary Sulfonamides

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journal contribution
posted on 16.04.2010 by David A. Powell, Hope Fan
A room-temperature, copper-catalyzed amination of primary benzylic C−H bonds with primary and secondary sulfonamides is described. The reaction is applicable to the coupling of a range of primary and secondary benzylic hydrocarbons with a diverse set of sulfonamides and is tolerant of substitution on both coupling partners. Factors which influence the selectivity of C−H functionalization between primary and secondary sites are examined.