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Copper-Catalyzed Selective Diphenylation of Carboxylic Acids with Cyclic Diaryliodonium Salts

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journal contribution
posted on 26.04.2017 by Hao Xie, Shuai Yang, Chunxia Zhang, Mingruo Ding, Min Liu, Jie Guo, Fengzhi Zhang
Herein, we describe a novel one-step copper-catalyzed diphenylation of readily available aliphatic or (hetero)­aromatic carboxylic acids with cyclic hypervalent diaryliodonium reagents. The selective diphenylation of benzoic acids with high atom economy can be achieved without observation of the arylation at the phenyl hydroxyl/thio/amino position. The valuable biphenyl esters with an additional iodo-substituent were obtained in good to excellent yields, which can be further transformed to diversified building blocks for the synthesis of bioactive natural products, pharmaceuticals, and functional materials. A wide range of different functional groups are compatible under the optimized reaction conditions.