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Copper-Catalyzed Borylative Cyclization of in Situ Generated o‑Allenylaryl Nitriles with Bis(pinacolato)­diboron

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journal contribution
posted on 26.06.2017 by Meijun Xiong, Xin Xie, Yuanhong Liu
A Cu-catalyzed cascade borylcupration/cyclization of in situ generated allene-nitriles with B2pin2 has been developed, which provides highly substituted 3-boryl-1-naphthyl­amines with excellent regioselectivity and wide functional group compatibility. It has been shown that, for the first time, the catalytically generated allylcopper species can be captured by a cyano group from a normal nitrile to furnish a carbocycle.