Copper-Catalyzed Borylative Cyclization of in Situ Generated o‑Allenylaryl Nitriles with Bis(pinacolato)diboron
journal contributionposted on 26.06.2017 by Meijun Xiong, Xin Xie, Yuanhong Liu
Any type of content formally published in an academic journal, usually following a peer-review process.
A Cu-catalyzed cascade borylcupration/cyclization of in situ generated allene-nitriles with B2pin2 has been developed, which provides highly substituted 3-boryl-1-naphthylamines with excellent regioselectivity and wide functional group compatibility. It has been shown that, for the first time, the catalytically generated allylcopper species can be captured by a cyano group from a normal nitrile to furnish a carbocycle.