Copper-Catalyzed Amino-oxymethylation of Ynamides with N,O‑Acetals
journal contributionposted on 28.10.2019 by Jianliang Yu, Guangyang Xu, Shengbiao Tang, Ying Shao, Jiangtao Sun
Any type of content formally published in an academic journal, usually following a peer-review process.
A copper-catalyzed 1,2-difunctionalization of ynamides has been developed by using readily available N,O-acetals as the bifunctional reagents. Importantly, contrary to the initially expected 1,2-oxy-aminomethylation reaction, an unprecedented 1,2-amino-oxymethylation has been observed. This reaction is atom-economical and tolerates a broad substrate scope, affording the difunctionalization products in good yield with unique Z configuration.