Conjugated Polymer Nanoparticles with Absorption beyond 1000 nm for NIR-II Fluorescence Imaging System Guided NIR-II Photothermal Therapy
journal contributionposted on 22.07.2020 by Xingwen Song, Xiaomei Lu, Bo Sun, Hua Zhang, Pengfei Sun, Han Miao, Quli Fan, Wei Huang
Any type of content formally published in an academic journal, usually following a peer-review process.
The second near-infrared fluorescence imaging (NIR-II FI) guided NIR-II photothermal therapy (PTT) possesses advantages for cancer treatment because of its accurate diagnosis and enhanced therapeutic effects for cancer. However, developing a conjugated polymer with both excellent NIR-II fluorescence and NIR-II PTT properties encountered many hindrances, including strong nonradiative decay, low solubility in organic solution, and significant aggregation-caused quenching (ACQ) effect. Herein, a conjugated polymer TTQ-2TC with optimized absorption in NIR-II regions, good solubility in organic solvents, and bright NIR-II FI signals is obtained through introducing the alkyl-side-chain-modified bithiophene (2TC) as the electron-rich donor unit. The water-soluble nanoparticle (TTQ-2TC NPs) prepared from the conjugated polymer TTQ-2TC is used for precise NIR-II FI guided NIR-II PTT treatment. The in vivo blood and tumor imaging and therapy results show that the TTQ-2TC NPs possess high signal-to-background ratio (SBR) and perfect antitumor efficacy by NIR-II PTT.