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Conformational Preferences of Zampanolide and Dactylolide

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journal contribution
posted on 18.10.2013 by Erik M. Larsen, Matthew R. Wilson, Jaroslav Zajicek, Richard E. Taylor
The solution conformation behavior of the macrolide core of microtubule-stabilizing agents (−)-zampanolide and (−)-dactylolide has been determined through a combination of high-field NMR experiments and computational modeling. Taken together, the results demonstrate that in solution both molecules exist as a mixture of three interconverting conformational families, one of which bears strong resemblance to zampanolide’s tubulin-bound conformation.