Conformational Preferences of Zampanolide and Dactylolide
journal contributionposted on 18.10.2013 by Erik M. Larsen, Matthew R. Wilson, Jaroslav Zajicek, Richard E. Taylor
Any type of content formally published in an academic journal, usually following a peer-review process.
The solution conformation behavior of the macrolide core of microtubule-stabilizing agents (−)-zampanolide and (−)-dactylolide has been determined through a combination of high-field NMR experiments and computational modeling. Taken together, the results demonstrate that in solution both molecules exist as a mixture of three interconverting conformational families, one of which bears strong resemblance to zampanolide’s tubulin-bound conformation.