Concise Syntheses of Meridianins and Meriolins Using a Catalytic Domino Amino-Palladation Reaction
journal contributionposted on 07.02.2014 by Scott R. Walker, Milena L. Czyz, Jonathan C. Morris
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A synthesis of natural and synthetic members of the meridianin family of kinase inhibitory natural products has been developed. The sequence utilizes a variation of the Cacchi palladium-catalyzed domino reaction to efficiently construct the heterocyclic framework of the meridianins and meriolins from monocyclic precursors.