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Coibacins A–D, Antileishmanial Marine Cyanobacterial Polyketides with Intriguing Biosynthetic Origins

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journal contribution
posted on 03.08.2012 by Marcy J. Balunas, Manuel F. Grosso, Francisco A. Villa, Niclas Engene, Kerry L. McPhail, Kevin Tidgewell, Laura M. Pineda, Lena Gerwick, Carmenza Spadafora, Dennis E. Kyle, William H. Gerwick
Four unsaturated polyketide lactone derivatives, coibacins A–D, were isolated from a Panamanian marine cyanobacterium, cf. Oscillatoria sp. The two different types of termini observed in these co-occurring metabolites, either a methyl cyclopropyl ring as seen in curacin A or a methyl vinyl chloride similar to that observed in the jamaicamides, suggest an intriguing flexibility in the “beta branch” forming biosynthetic process. The coibacins possess selective antileishmanial activity as well as potent anti-inflammatory activity.