Cobalt(III)- and Rhodium(III)-Catalyzed C–H Amidation and Synthesis of 4‑Quinolones: C–H Activation Assisted by Weakly Coordinating and Functionalizable Enaminone
journal contributionposted on 30.03.2017 by Fen Wang, Liang Jin, Lingheng Kong, Xingwei Li
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Cobalt(III) and rhodium(III) catalysts exhibited complementary scope in C–H amidation of aryl enaminones. The amidation reactions proceeded with broad scope under the assistance of a weakly coordinating and bifunctional enaminone directing group. The electrophilicity of the enaminone group can be further utilized in subsequent hydrolysis–cyclization reactions to afford NH 4-quinolones in telescoping reactions.