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Cobalt-Catalyzed Ortho-Arylation of Aromatic Imines with Aryl Chlorides

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journal contribution
posted on 17.08.2012 by Ke Gao, Pin-Sheng Lee, Chong Long, Naohiko Yoshikai
An ortho-arylation reaction of aromatic imines with aryl chlorides has been achieved using a cobalt–N-heterocyclic carbene catalyst in combination with a neopentyl Grignard reagent. The reaction takes place at room temperature to afford biaryl products in moderate to good yields.