Cinnamtannin D‑1 Protects Pancreatic β‑Cells from Palmitic Acid-Induced Apoptosis by Attenuating Oxidative Stress
journal contributionposted on 04.06.2014 by Ting Wang, Peng Sun, Liang Chen, Qi Huang, Kaixian Chen, Qi Jia, Yiming Li, Heyao Wang
Any type of content formally published in an academic journal, usually following a peer-review process.
In previous studies, A-type procyanidin oligomers isolated from Cinnamomum tamala were proved to possess antidiabetic effect and protect pancreatic β-cells in vivo. The aim of this study was to unveil the mechanisms of protecting pancreatic β-cells from palmitic acid-induced apoptosis by cinnamtannin D-1 (CD1), one of the main A-type procyanidin oligomers in C. tamala. CD1 was discovered to dose-dependently reduce palmitic acid- or H2O2-induced apoptosis and oxidative stress in INS-1 cells, MIN6 cells, and primary cultured murine islets. Moreover, CD1 could reverse palmitic acid-induced dysfunction of glucose-stimulated insulin secretion in primary cultured islets. These results indicate that reduction of apoptosis and oxidative stress might account for the protection effect of CD1, which provided a better understanding of the mechanisms of the antidiabetic effects of procyanidin oligomers.