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Characteristic α‑Acid Derivatives from Humulus lupulus with Antineuroinflammatory Activities

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journal contribution
posted on 20.11.2017 by Jiayuan Li, Ning Li, Xuezheng Li, Gang Chen, Cungang Wang, Bin Lin, Yue Hou
Twenty compounds, including 14 new α-acid derivatives, a new chromone, and five known compounds, were identified from the pistillate inflorescence of Humulus lupulus (hops), and their structures were elucidated via physical data analysis. The absolute configurations of new α-acid derivatives 111b were determined by comparing their computed and experimental electronic circular dichroism spectra using TDDFT and NMR spectroscopic data. A putative biosynthetic pathway for the identified components was deduced. Their antineuroinflammatory effects were assayed systematically, and their structure–activity relationships are discussed briefly. Among the identified compounds, compound 14 displayed moderate inhibitory effects against nitric oxide production with an IC50 value of 7.92 μM.