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Cellular Uptake of PNA−Terpyridine Conjugates and Its Enhancement by Zn2+ Ions

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journal contribution
posted on 10.05.2006 by Andreas Füssl, Andreas Schleifenbaum, Mareike Göritz, Andrew Riddell, Carsten Schultz, Roland Krämer
Conjugation of usually impermeable peptide nucleic acids (PNA) to the chelator 2,2‘:6‘,2‘ ‘-terpyridine strongly promotes cellular and nuclear uptake by cultured HeLa cells. Cellular accumulation is further enhanced in the presence of extracellular Zn2+.