Cationic Gold Catalyzes ω-Bromination of Terminal Alkynes and Subsequent Hydroaddition Reactions
journal contributionposted on 03.06.2011 by Antonio Leyva-Pérez, Paula Rubio-Marqués, Salem S. Al-Deyab, Saud I. Al-Resayes, Avelino Corma
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Orthogonal σ,π-bisfunctionalization of terminal alkynes can be achieved with a cationic gold complex in catalytic amounts. First, the terminal C–H bond is transformed to the corresponding bromoalkyne which is then activated toward nucleophilic attack. This reactivity correlates with the structural nature of isolated gold-alkyne complexes.