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Catalytic Intermolecular Cross-Couplings of Azides and LUMO-Activated Unsaturated Acyl Azoliums

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journal contribution
posted on 15.02.2017, 00:00 by Wenjun Li, Manjaly J. Ajitha, Ming Lang, Kuo-Wei Huang, Jian Wang
An example for the catalytic synthesis of densely functionalized 1,2,3-triazoles through a LUMO activation mode has been developed. The protocol is enabled by intermolecular cross-coupling reactions of azides with in situ-generated α,β-unsaturated acyl azoliums. High yields and broad scope as well as the investigation of reaction mechanism are reported.