Catalytic Asymmetric Sulfenylation of Unprotected 3-Substituted Oxindoles
journal contributionposted on 01.06.2012 by Yunfei Cai, Jun Li, Weiliang Chen, Mingsheng Xie, Xiaohua Liu, Lili Lin, Xiaoming Feng
Any type of content formally published in an academic journal, usually following a peer-review process.
Catalytic asymmetric sulfenylation of unprotected 3-substituted oxindoles has been developed via cooperative catalysis of a chiral N,N′-dioxide–Sc(OTf)3 complex and a Brønsted base. Utilizing readily available N-(phenylthio)phthalimide as the sulfur source, a wide range of optically active 3-phenylthiooxindoles were obtained in excellent yields with excellent enantioselectivities under mild reaction conditions.