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Caged Ceramide 1-Phosphate Analogues: Synthesis and Properties

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journal contribution
posted on 20.11.2009 by Ravi S. Lankalapalli, Alberto Ouro, Lide Arana, Antonio Gómez-Muñoz, Robert Bittman
Sphingolipid phosphate analogues bearing 7-(diethylamino)coumarin (DECM) and 4-bromo-5-hydroxy-2-nitrobenzhydryl (BHNB) groups in a photolabile ester bond were synthesized. The ability of the “caged” ceramide 1-phosphate analogues to release the bioactive parent molecule upon irradiation at 400−500 nm was demonstrated by stimulation of macrophage cell proliferation.