Caelestines A−D, Brominated Quinolinecarboxylic Acids from the Australian Ascidian Aplidium caelestis
journal contributionposted on 24.09.2010 by Sheng Yin, Glen M. Boyle, Anthony R. Carroll, Michael Kotiw, John Dearnaley, Ronald J. Quinn, Rohan A. Davis
Any type of content formally published in an academic journal, usually following a peer-review process.
Four new brominated natural products, caelestines A−D (1−4), have been isolated from the Australian ascidian Aplidium caelestis. The structures of 1−4 were determined by analysis of their NMR and MS data. This is the first report of brominated quinolinecarboxylic acids from nature. Compound 1 has been previously synthesized but not spectroscopically characterized. Compounds 1−4 were tested against three mammalian cell lines (MCF-7, NFF, and MM96L) and a panel of microbial strains and showed only minor cytotoxicity.