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Borane-Catalyzed Transfer Hydrogenations of Pyridines with Ammonia Borane

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journal contribution
posted on 28.09.2016 by Qiwen Zhou, Lanqiong Zhang, Wei Meng, Xiangqing Feng, Jing Yang, Haifeng Du
With the use of ammonia borane as a hydrogen source, a borane catalyzed metal-free transfer hydrogenation of pyridines was successfully realized for the first time to furnish a variety of piperidines in 44–88% yields with moderate to excellent cis-selectivities. The ease in handling without requiring high pressure H2 makes this transfer hydrogenation practical and useful.