Bioinspired Total Synthesis of Bussealin E
journal contributionposted on 01.03.2018 by David G. Twigg, Leonardo Baldassarre, Elizabeth C. Frye, Warren R. J. D. Galloway, David R. Spring
Any type of content formally published in an academic journal, usually following a peer-review process.
The first total synthesis of bussealin E, a natural product with a unique cycloheptadibenzofuran scaffold, is reported. A strategy inspired by a proposed biosynthesis was employed whereby a diphenylpropane derivative underwent an oxidative phenolic coupling to forge the tetracyclic ring system. The synthesis of the diphenylpropane featured a key sp2–sp3 Hiyama coupling between a vinyldisiloxane and a benzylic bromide.