Bioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons
journal contributionposted on 29.12.2015 by Nicholas Stephanopoulos, Ronit Freeman, Hilary A. North, Shantanu Sur, Su Ji Jeong, Faifan Tantakitti, John A. Kessler, Samuel I. Stupp
Any type of content formally published in an academic journal, usually following a peer-review process.
We report the construction of DNA nanotubes covalently functionalized with the cell adhesion peptide RGDS as a bioactive substrate for neural stem cell differentiation. Alteration of the Watson–Crick base pairing program that builds the nanostructures allowed us to probe independently the effect of nanotube architecture and peptide bioactivity on stem cell differentiation. We found that both factors instruct synergistically the preferential differentiation of the cells into neurons rather than astrocytes.