Berkeleydione and Berkeleytrione, New Bioactive Metabolites from an Acid Mine Organism
journal contributionposted on 18.03.2004 by Donald B. Stierle, Andrea A. Stierle, J. David Hobbs, Janalee Stokken, Jon Clardy
Any type of content formally published in an academic journal, usually following a peer-review process.
Two novel hybrid polyketide-terpenoid metabolites were isolated from a Penicillium sp. growing in the Berkeley Pit Lake of Butte, Montana. Their structures were deduced by spectroscopic analysis and confirmed by single-crystal X-ray analysis on berkeleydione (1). Both compounds inhibited matrix metalloproteinase-3 and caspase-1, and berkeleydione showed activity toward non-small-cell lung cancer in NCI's human cell line antitumor screen.