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Berkeleydione and Berkeleytrione, New Bioactive Metabolites from an Acid Mine Organism

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journal contribution
posted on 18.03.2004 by Donald B. Stierle, Andrea A. Stierle, J. David Hobbs, Janalee Stokken, Jon Clardy
Two novel hybrid polyketide-terpenoid metabolites were isolated from a Penicillium sp. growing in the Berkeley Pit Lake of Butte, Montana. Their structures were deduced by spectroscopic analysis and confirmed by single-crystal X-ray analysis on berkeleydione (1). Both compounds inhibited matrix metalloproteinase-3 and caspase-1, and berkeleydione showed activity toward non-small-cell lung cancer in NCI's human cell line antitumor screen.