Base−Base Interactions in the Minor Groove of Double-Stranded DNA
journal contributionposted on 21.07.2006 by Tongfei Wu, Koen Nauwelaerts, Arthur Van Aerschot, Matheus Froeyen, Eveline Lescrinier, Piet Herdewijn
Any type of content formally published in an academic journal, usually following a peer-review process.
A method has been developed for the synthesis of bisheaded nucleosides with thymine and adenine base moieties. We have demonstrated that, when incorporated in oligonucleotides, extrahelical A−T base interactions are possible when the bisheaded nucleosides are positioned in opposite strands of the duplex and are separated from each other by one regular base pair.