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Base−Base Interactions in the Minor Groove of Double-Stranded DNA

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posted on 21.07.2006 by Tongfei Wu, Koen Nauwelaerts, Arthur Van Aerschot, Matheus Froeyen, Eveline Lescrinier, Piet Herdewijn
A method has been developed for the synthesis of bisheaded nucleosides with thymine and adenine base moieties. We have demonstrated that, when incorporated in oligonucleotides, extrahelical A−T base interactions are possible when the bisheaded nucleosides are positioned in opposite strands of the duplex and are separated from each other by one regular base pair.

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