Asymmetric Synthesis of γ-Hydroxy α,β-Unsaturated Aldehydes via Enantioselective Direct Addition of Propargyl Acetate to Aldehydes
journal contributionposted on 23.08.2001 by Emad El-Sayed, Neel K. Anand, Erick M. Carreira
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We report the first example of enantioselective and diastereoselective aldehyde additions of propargyl acetate to aldehydes using the methodology recently reported from our laboratories. Subsequent O-silyl protection, Pd-catalyzed isomerization, AcOH addition, and hydrolysis result in optically active γ-hydroxy α,β-unsaturated aldehydes as powerful building blocks.