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Asnovolins A–G, Spiromeroterpenoids Isolated from the Fungus Aspergillus novofumigatus, and Suppression of Fibronectin Expression by Asnovolin E

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journal contribution
posted on 14.09.2016 by Kazuki Ishikawa, Fumiaki Sato, Takeshi Itabashi, Hiroshi Wachi, Hisashi Takeda, Daigo Wakana, Takashi Yaguchi, Ken-ichi Kawai, Tomoo Hosoe
Seven novel spiromeroterpenoids, asnovolins A–G (17), one of which was shown to suppress fibronectin expression, were isolated from Aspergillus novofumigatus CBS117520 along with a known compound, novofumigatonin (8). The structures of asnovolins A–G were elucidated using MS and 2D-NMR data. Asnovolin E (5) suppressed fibronectin expression by normal human neonatal dermal fibroblast cells.

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