Antiproliferative Prenylated Xanthones and Benzophenones from the Roots of Cudrania tricuspidata in HSC-T6 Cells
journal contributionposted on 26.11.2014, 00:00 by Yang Hee Jo, Bora Shin, Qing Liu, Ki Yong Lee, Dong-Chan Oh, Bang Yeon Hwang, Mi Kyeong Lee
Four new prenylated xanthones, cudracuspixanthones A–D (1–4), two new prenylated benzophenones, cudracuspiphenones A (5) and B (6), and 11 known xanthones (7–17) were isolated from the roots of Cudrania tricuspidata. The absolute configurations of compounds 2–4 were deduced by the comparison of the calculated optical rotation values with the measured data. Compounds 1, 5, and 6 showed moderate antiproliferative activity on HSC-T6 cells with IC50 values of 9.7, 3.3, and 7.1 μM, respectively. Compounds 2–4, 10, and 14–16 had weaker activity. Flow cytometric analysis suggested that compounds 1 and 5 inhibited HSC-T6 cell proliferation in part by inducing apoptosis.