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An Unexpected Reaction of Trimethylsilyl Fluorosulfonyldifluoroacetate (TFDA) with Imidazoles. Formation of N-Difluoromethylthioureas

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journal contribution
posted on 23.11.2006 by Wei Xu, Khalil A. Abboud, Ion Ghiviriga, William R. Dolbier,, Magdalena Rapp, Stanislaw F. Wnuk
A new reaction of the efficient difluorocarbene-generating reagent trimethylsilyl fluorosulfonyldifluoroacetate (TFDA) is reported in which molecules containing an N-alkylimidazole or benzimidazole structure undergo an unexpected one-pot conversion to N-difluoromethylthioureas.