ja0474493_si_001.pdf (470.69 kB)

An Extremely Active Catalyst for the Negishi Cross-Coupling Reaction

Download (470.69 kB)
journal contribution
posted on 13.10.2004 by Jacqueline E. Milne, Stephen L. Buchwald
A new catalyst system for the Pd-catalyzed cross-coupling of organozinc reagents with aryl halides (Negishi coupling) has been developed. This system permits efficient preparation of hindered biaryls (tri- and tetra-ortho-substituted), functions effectively at low levels of catalyst, and tolerates a wide range of functional groups and heterocyclic substrates. A systematic study of ligand structure was performed and was correlated with catalyst activity.