An Extremely Active Catalyst for the Negishi Cross-Coupling Reaction
journal contributionposted on 13.10.2004 by Jacqueline E. Milne, Stephen L. Buchwald
Any type of content formally published in an academic journal, usually following a peer-review process.
A new catalyst system for the Pd-catalyzed cross-coupling of organozinc reagents with aryl halides (Negishi coupling) has been developed. This system permits efficient preparation of hindered biaryls (tri- and tetra-ortho-substituted), functions effectively at low levels of catalyst, and tolerates a wide range of functional groups and heterocyclic substrates. A systematic study of ligand structure was performed and was correlated with catalyst activity.