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Additional Scalarane Sesterterpenes from the Sponge Phyllospongia papyracea

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journal contribution
posted on 02.04.2020, 14:50 by Hou-Jin Li, Taro Amagata, Karen Tenney, Phillip Crews
A chemical investigation of the marine sponge Phyllospongia papyracea, collected in Papua New Guinea, initiated by the screening result of a β-catenin/Tcf4 disruption assay afforded six new bishomoscalarane sesterterpenes containing two rare scalaranes with a cyclobutane ring in the molecule, together with one known scalarane sesterterpene. The structures of the new compounds were elucidated by 1D and 2D spectroscopic techniques. The compounds isolated in this study did not show activity against the β-catenin and Tcf4 complex.

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