Adaptable to Mechanically Stable Hydrogels Based on the Dynamic Covalent Cross-Linking of Thiol-Aldehyde Addition
journal contributionposted on 04.03.2019, 13:35 by Yujie Hua, Yibo Gan, Yiqing Zhang, Bin Ouyang, Bing Tu, Chengmin Zhang, Xuepeng Zhong, Chunyan Bao, Yi Yang, Qiuning Lin, Qiang Zhou, Linyong Zhu
Any type of content formally published in an academic journal, usually following a peer-review process.
We exploit the thiol-aldehyde addition (TAA) reaction to build a dynamic covalent cross-linking (DCC) hydrogel in the physiological-pH environment. Due to the rapid and reversible TAA reaction, the resulting hydrogels are readily adapted for convenient manipulation, for example, free molding, easy injection, and self-healing. Meanwhile, the labile hemithioacetal bonds within the DCC hydrogel can convert to thermodynamically stable bonds via spontaneous thiol transfer reactions, thereby realizing poststabilization as needed. The successful application as a long-term scaffold for repair of barely self-healed bone defect indicated the hydrogels with both adaptability and mechanical stability based on thiol-aldehyde addition reaction is significant for biomedical areas.