Access to Lactone Building Blocks via Horse Liver Alcohol Dehydrogenase-Catalyzed Oxidative Lactonization
journal contributionposted on 01.11.2013 by Selin Kara, Dominik Spickermann, Joerg H. Schrittwieser, Andrea Weckbecker, Christian Leggewie, Isabel W. C. E. Arends, Frank Hollmann
Any type of content formally published in an academic journal, usually following a peer-review process.
The oxidative lactonization of 1,4-, 1,5-, and 1,6-diols using horse liver alcohol dehydrogenase (HLADH) is reported. Molecular oxygen was used as terminal electron acceptor by utilization of the laccase-mediator concept to regenerate the oxidized nicotinamide cofactor and producing water as sole byproduct. Spontaneous hydrolysis of the lactone products was identified as a major limiting factor toward preparative application of the system, which can be alleviated by using a two liquid phase approach to extracting the product into an organic solvent.