jo9b01872_si_001.pdf (3.07 MB)
0/0

Access to Isothiazolones from Simple Acrylamides by Pd-Catalyzed C–H Bond Activation

Download (3.07 MB)
journal contribution
posted on 19.08.2019 by Mu-Yi Chen, Xavier Pannecoucke, Philippe Jubault, Tatiana Besset
A new methodology was developed to access isothiazolone derivatives from simple acrylamides by transition metal catalyzed C–H bond functionalization. This Pd-catalyzed reaction using an electrophilic SCN source offered an efficient tool to access a panel of functionalized isothiazolone derivatives (21 examples, up to 71% yield).

History

Exports