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Access to Isothiazolones from Simple Acrylamides by Pd-Catalyzed C–H Bond Activation

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journal contribution
posted on 19.08.2019 by Mu-Yi Chen, Xavier Pannecoucke, Philippe Jubault, Tatiana Besset
A new methodology was developed to access isothiazolone derivatives from simple acrylamides by transition metal catalyzed C–H bond functionalization. This Pd-catalyzed reaction using an electrophilic SCN source offered an efficient tool to access a panel of functionalized isothiazolone derivatives (21 examples, up to 71% yield).