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A Three-Component Tandem Reductive Aldol Reaction Catalyzed by N-Heterocyclic Carbene−Copper Complexes

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journal contribution
posted on 21.12.2006, 00:00 by Alexandre Welle, Silvia Díez-González, Bernard Tinant, Steven P. Nolan, Olivier Riant
An efficient catalytic system for the three-component coupling of electrophilic alkenes, aldehydes, and silane was optimized with a new family of copper N-heterocyclic carbene complexes. These catalysts do not require activation and show high activity (TOF > 15 000 h-1) as well as some anti diastereoselectivity.